Arthritis in primary Sjögren's syndrome: Characteristics, outcome and treatment from French multicenter retrospective study
Identifieur interne : 000239 ( an2020/Analysis ); précédent : 000238; suivant : 000240Arthritis in primary Sjögren's syndrome: Characteristics, outcome and treatment from French multicenter retrospective study
Auteurs : Adrien Mirouse [France] ; Raphaele Séror [France] ; Eric Vicaut [France] ; Xavier Mariette [France] ; Maxime Dougados [France] ; Anne-Laure Fauchais [France] ; Alban Deroux [France] ; Azeddine Dellal [France] ; Nathalie Costedoat-Chalumeau [France] ; Guillaume Denis [France] ; Jeremie Sellam [France] ; Jean-Benoît Arlet [France] ; Christian Lavigne [France] ; Geoffrey Urbanski [France] ; Dominique Fischer-Dumont [France] ; Abdou Diallo [France] ; Olivier Fain [France] ; Arsène Mékinian [France]Source :
- Autoimmunity Reviews [ 1568-9972 ] ; 2019.
English descriptors
Abstract
OBJECTIVE: To describe the characteristics and the outcome of primary Sjögren Syndrome (pSS) associated arthritis and to compare the efficacy of different therapeutic regimen.METHODS: We conducted a retrospective study using Club Rhumatisme and Inflammation (CRI) and French Internal Medicine Society (SNFMI) networks. All patients with a diagnosis of pSS and at least one episode of clinical and/or echographic synovitis were included. Patients with synovitis (cases) were compared to pSS patients without synovitis (controls).RESULTS: 57 patients (93% women) were included with a median age of 54 years [45-63]. Patients with synovitis had more frequently lymph node enlargement (12.3% vs. 1.8%, p = .007) and a higher ESSDAI score (8 [6-12] vs. 2 [1-4], p < .0001). There was no difference concerning CRP levels, rheumatoid factor and cyclic citrullinated peptide (CCP)-antibodies positivity. Among 57 patients with synovitis, 101 various treatment courses have been used during the follow-up of 40 [22.5-77] months. First treatment course consisted in steroids alone (3.5%), steroids in association (79%) with hydroxychloroquine (HCQ) (49%), methotrexate (MTX) (35%), rituximab (RTX) (5.3%) or other immunosuppressive drugs (7%). HCQ, MTX, and RTX were associated with a significant reduction of tender and swollen joint count, and a significant steroids-sparing effect. No difference could be shown for the joint response between these treatment regimens.CONCLUSION: pSS articular manifestations may include synovitis which could mimic rheumatoid arthritis but differ by the absence of structural damage. Even if the use of HCQ, MTX, and RTX seem to be effective for joint involvement, the best regimen remains to be determined.
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DOI: 10.1016/j.autrev.2018.06.015
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Paris 7</orgName> <orgName type="acronym">UPD7</orgName> <desc> <address> <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris-diderot.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Fain, Olivier" sort="Fain, Olivier" uniqKey="Fain O" first="Olivier" last="Fain">Olivier Fain</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-413221" status="VALID"> <orgName>Sorbonne Université</orgName> <orgName type="acronym">SU</orgName> <date type="start">2018-01-01</date> <desc> <address> <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.sorbonne-universite.fr/</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Mekinian, Arsene" sort="Mekinian, Arsene" uniqKey="Mekinian A" first="Arsène" last="Mékinian">Arsène Mékinian</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-413221" status="VALID"> <orgName>Sorbonne Université</orgName> <orgName type="acronym">SU</orgName> <date type="start">2018-01-01</date> <desc> <address> <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.sorbonne-universite.fr/</ref> </desc> </hal:affiliation><country>France</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">HAL</idno><idno type="RBID">Hal:hal-02171337</idno><idno type="halId">hal-02171337</idno><idno type="halUri">https://hal.sorbonne-universite.fr/hal-02171337</idno><idno type="url">https://hal.sorbonne-universite.fr/hal-02171337</idno><idno type="doi">10.1016/j.autrev.2018.06.015</idno><date when="2019">2019</date><idno type="wicri:Area/Hal/Corpus">000030</idno><idno type="wicri:Area/Hal/Curation">000030</idno><idno type="wicri:Area/Hal/Checkpoint">000020</idno><idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000020</idno><idno type="wicri:doubleKey">1568-9972:2019:Mirouse A:arthritis:in:primary</idno><idno type="wicri:Area/Main/Merge">000251</idno><idno type="wicri:Area/Main/Curation">000251</idno><idno type="wicri:Area/Main/Exploration">000251</idno><idno type="wicri:Area/an2020/Extraction">000239</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Arthritis in primary Sjögren's syndrome: Characteristics, outcome and treatment from French multicenter retrospective study</title><author><name sortKey="Mirouse, Adrien" sort="Mirouse, Adrien" uniqKey="Mirouse A" first="Adrien" last="Mirouse">Adrien Mirouse</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-541912" status="VALID"> <idno type="RNSR">200918542V</idno> <orgName>Centre de Recherche Saint-Antoine</orgName> <orgName type="acronym">CR Saint-Antoine</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation name="U938" active="#struct-303623" type="direct"></relation> <relation active="#struct-413221" type="direct"></relation> </listRelation> <tutelles><tutelle name="U938" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-413221" type="direct"><org type="institution" xml:id="struct-413221" status="VALID"> <orgName>Sorbonne Université</orgName> <orgName type="acronym">SU</orgName> <date type="start">2018-01-01</date> <desc> <address> <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.sorbonne-universite.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Seror, Raphaele" sort="Seror, Raphaele" uniqKey="Seror R" first="Raphaele" last="Séror">Raphaele Séror</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-18212" status="VALID"> <orgName>Service de rhumatologie</orgName> <desc> <address> <addrLine>Le Kremlin-Bicêtre</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-92966" type="direct"></relation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-300148" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-92966" type="direct"><org type="institution" xml:id="struct-92966" status="VALID"> <orgName>Université Paris-Sud - Paris 11</orgName> <orgName type="acronym">UP11</orgName> <desc> <address> <addrLine>Bâtiment 300 - 91405 Orsay cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.u-psud.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300148" type="direct"><org type="institution" xml:id="struct-300148" status="VALID"> <orgName>Hôpital Bicêtre</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Vicaut, Eric" sort="Vicaut, Eric" uniqKey="Vicaut E" first="Eric" last="Vicaut">Eric Vicaut</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-26729" status="OLD"> <orgName>Hôpital Lariboisière</orgName> <date type="end">2019-12-31</date> <desc> <address> <addrLine>2, rue Ambroise - Paré 75475 Paris Cedex 10</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-300128" type="direct"></relation> <relation active="#struct-300301" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300128" type="direct"><org type="institution" xml:id="struct-300128" status="VALID"> <orgName>Hôpital Lariboisière</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="VALID"> <idno type="ISNI">0000000121514068</idno> <idno type="IdRef">027542084</idno> <orgName>Université Paris Diderot - Paris 7</orgName> <orgName type="acronym">UPD7</orgName> <desc> <address> <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris-diderot.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-312432" status="VALID"> <orgName>AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre)</orgName> <desc> <address> <addrLine>78 Rue du Général Leclerc 94270 Le Kremlin-Bicêtre</addrLine> <country key="FR"></country> </address> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Dougados, Maxime" sort="Dougados, Maxime" uniqKey="Dougados M" first="Maxime" last="Dougados">Maxime Dougados</name><affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-18258" status="VALID"> <orgName>Service de rhumatologie [CHU Cochin]</orgName> <desc> <address> <addrLine>27 rue du Faubourg Saint-Jacques 75014 Paris</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300123" type="direct"></relation> <relation active="#struct-300068" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300123" type="direct"><org type="institution" xml:id="struct-300123" status="VALID"> <orgName>CHU Cochin [AP-HP]</orgName> <desc> <address> <addrLine>27 Rue du Faubourg Saint-Jacques 75014 Paris</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - 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Paris 7</orgName> <orgName type="acronym">UPD7</orgName> <desc> <address> <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris-diderot.fr</ref> </desc> </org></tutelle><tutelle active="#struct-301664" type="direct"><org type="institution" xml:id="struct-301664" status="OLD"> <idno type="IdRef">026404788</idno> <idno type="ISNI">0000 0001 2188 0914 </idno> <orgName>Université Paris Descartes - Paris 5</orgName> <orgName type="acronym">UPD5</orgName> <date type="start">1971-01-01</date> <date type="end">2019-12-31</date> <desc> <address> <addrLine>12, rue de l'École de Médecine - 75270 Paris cedex 06</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.parisdescartes.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-303171" type="direct"><org type="regroupinstitution" xml:id="struct-303171" status="VALID"> <orgName>Université Sorbonne Paris Cité</orgName> <orgName type="acronym">USPC</orgName> <date type="start">2010</date> <desc> <address> <addrLine>Université Sorbonne Paris Cité | 100-104, avenue de France | 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.sorbonne-paris-cite.fr/fr</ref> </desc> </org></tutelle><tutelle name="U1153" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Denis, Guillaume" sort="Denis, Guillaume" uniqKey="Denis G" first="Guillaume" last="Denis">Guillaume Denis</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-13338" status="VALID"> <idno type="IdRef">067103510</idno> <idno type="RNSR">199814201Z</idno> <orgName>Laboratoire d’Électrotechnique et d’Électronique de Puissance - 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75006 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.sorbonne-universite.fr/</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Arlet, Jean Benoit" sort="Arlet, Jean Benoit" uniqKey="Arlet J" first="Jean-Benoît" last="Arlet">Jean-Benoît Arlet</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-204525" status="VALID"> <orgName>Service de Médecine Interne [CHU HEGP]</orgName> <desc> <address> <addrLine>20, rue Leblanc 75015 Paris</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-300119" type="direct"></relation> <relation active="#struct-353414" type="indirect"></relation> <relation active="#struct-341272" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300119" type="direct"><org type="institution" xml:id="struct-300119" status="VALID"> <orgName>Hôpital Européen Georges Pompidou [APHP]</orgName> <orgName type="acronym">HEGP</orgName> <desc> <address> <addrLine>20, rue Leblanc, 75015 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://hopital-georgespompidou.aphp.fr/</ref> </desc> <listRelation> <relation active="#struct-353414" type="direct"></relation> <relation active="#struct-300068" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-353414" type="indirect"><org type="regroupinstitution" xml:id="struct-353414" status="VALID"> <orgName>Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest</orgName> <orgName type="acronym">HUPO</orgName> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://hopitaux-parisouest.aphp.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-341272" type="direct"><org type="institution" xml:id="struct-341272" status="INCOMING"> <orgName>Centre de référence des syndromes drépanocytaires majeurs</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Lavigne, Christian" sort="Lavigne, Christian" uniqKey="Lavigne C" first="Christian" last="Lavigne">Christian Lavigne</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-186833" status="VALID"> <orgName>Service de médecine interne et gérontologie clinique [Angers]</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-74911" type="direct"></relation> <relation active="#struct-151939" type="direct"></relation> <relation active="#struct-301358" type="indirect"></relation> </listRelation> <tutelles><tutelle active="#struct-74911" type="direct"><org type="institution" xml:id="struct-74911" status="VALID"> <idno type="IdRef">026402920</idno> <idno type="ISNI">0000000122483363</idno> <orgName>Université d'Angers</orgName> <orgName type="acronym">UA</orgName> <date type="start">1971-10-25</date> <desc> <address> <addrLine>Université d'Angers - 40 Rue de Rennes, BP 73532 - 49035 Angers CEDEX 01</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-angers.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-151939" type="direct"><org type="institution" xml:id="struct-151939" status="VALID"> <orgName>Centre Hospitalier Universitaire d'Angers</orgName> <orgName type="acronym">CHU Angers</orgName> <desc> <address> <addrLine>4 rue Larrey - 49933 Angers cedex 9</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-angers.fr/</ref> </desc> <listRelation> <relation active="#struct-301358" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301358" type="indirect"><org type="regroupinstitution" xml:id="struct-301358" status="OLD"> <idno type="IdRef">187401039</idno> <orgName>PRES Université Nantes Angers Le Mans</orgName> <orgName type="acronym">UNAM</orgName> <date type="start">2008-12-31</date> <date type="end">2016-01-01</date> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Angers</settlement><region type="region" nuts="2">Pays de la Loire</region></placeName><orgName type="university">Université d'Angers</orgName></affiliation></author><author><name sortKey="Urbanski, Geoffrey" sort="Urbanski, Geoffrey" uniqKey="Urbanski G" first="Geoffrey" last="Urbanski">Geoffrey Urbanski</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-186833" status="VALID"> <orgName>Service de médecine interne et gérontologie clinique [Angers]</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-74911" type="direct"></relation> <relation active="#struct-151939" type="direct"></relation> <relation active="#struct-301358" type="indirect"></relation> </listRelation> <tutelles><tutelle active="#struct-74911" type="direct"><org type="institution" xml:id="struct-74911" status="VALID"> <idno type="IdRef">026402920</idno> <idno type="ISNI">0000000122483363</idno> <orgName>Université d'Angers</orgName> <orgName type="acronym">UA</orgName> <date type="start">1971-10-25</date> <desc> <address> <addrLine>Université d'Angers - 40 Rue de Rennes, BP 73532 - 49035 Angers CEDEX 01</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-angers.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-151939" type="direct"><org type="institution" xml:id="struct-151939" status="VALID"> <orgName>Centre Hospitalier Universitaire d'Angers</orgName> <orgName type="acronym">CHU Angers</orgName> <desc> <address> <addrLine>4 rue Larrey - 49933 Angers cedex 9</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-angers.fr/</ref> </desc> <listRelation> <relation active="#struct-301358" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301358" type="indirect"><org type="regroupinstitution" xml:id="struct-301358" status="OLD"> <idno type="IdRef">187401039</idno> <orgName>PRES Université Nantes Angers Le Mans</orgName> <orgName type="acronym">UNAM</orgName> <date type="start">2008-12-31</date> <date type="end">2016-01-01</date> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Angers</settlement><region type="region" nuts="2">Pays de la Loire</region></placeName><orgName type="university">Université d'Angers</orgName></affiliation></author><author><name sortKey="Fischer Dumont, Dominique" sort="Fischer Dumont, Dominique" uniqKey="Fischer Dumont D" first="Dominique" last="Fischer-Dumont">Dominique Fischer-Dumont</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-116551" status="OLD"> <orgName>Hôpital avicenne</orgName> <date type="end">2019-12-31</date> <desc> <address> <addrLine>125, rue de Stalingrad 93000 Bobigny</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-15786" type="direct"></relation> <relation active="#struct-300210" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-15786" type="direct"><org type="institution" xml:id="struct-15786" status="VALID"> <orgName>Université Paris 13</orgName> <orgName type="acronym">UP13</orgName> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris13.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-300210" type="direct"><org type="institution" xml:id="struct-300210" status="VALID"> <orgName>Hôpital Avicenne</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="university">Université Paris 13</orgName></affiliation></author><author><name sortKey="Diallo, Abdou" sort="Diallo, Abdou" uniqKey="Diallo A" first="Abdou" last="Diallo">Abdou Diallo</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-26729" status="OLD"> <orgName>Hôpital Lariboisière</orgName> <date type="end">2019-12-31</date> <desc> <address> <addrLine>2, rue Ambroise - Paré 75475 Paris Cedex 10</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-300128" type="direct"></relation> <relation active="#struct-300301" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300128" type="direct"><org type="institution" xml:id="struct-300128" status="VALID"> <orgName>Hôpital Lariboisière</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="VALID"> <idno type="ISNI">0000000121514068</idno> <idno type="IdRef">027542084</idno> <orgName>Université Paris Diderot - Paris 7</orgName> <orgName type="acronym">UPD7</orgName> <desc> <address> <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris-diderot.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Fain, Olivier" sort="Fain, Olivier" uniqKey="Fain O" first="Olivier" last="Fain">Olivier Fain</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-413221" status="VALID"> <orgName>Sorbonne Université</orgName> <orgName type="acronym">SU</orgName> <date type="start">2018-01-01</date> <desc> <address> <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.sorbonne-universite.fr/</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Mekinian, Arsene" sort="Mekinian, Arsene" uniqKey="Mekinian A" first="Arsène" last="Mékinian">Arsène Mékinian</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-413221" status="VALID"> <orgName>Sorbonne Université</orgName> <orgName type="acronym">SU</orgName> <date type="start">2018-01-01</date> <desc> <address> <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.sorbonne-universite.fr/</ref> </desc> </hal:affiliation><country>France</country></affiliation></author></analytic><idno type="DOI">10.1016/j.autrev.2018.06.015</idno><series><title level="j">Autoimmunity Reviews</title><idno type="ISSN">1568-9972</idno><imprint><date type="datePub">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>DMARDS</term><term>Primary Sjögren's syndrome</term><term>Rituximab</term><term>Synovitis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>OBJECTIVE: To describe the characteristics and the outcome of primary Sjögren Syndrome (pSS) associated arthritis and to compare the efficacy of different therapeutic regimen.METHODS: We conducted a retrospective study using Club Rhumatisme and Inflammation (CRI) and French Internal Medicine Society (SNFMI) networks. All patients with a diagnosis of pSS and at least one episode of clinical and/or echographic synovitis were included. Patients with synovitis (cases) were compared to pSS patients without synovitis (controls).RESULTS: 57 patients (93% women) were included with a median age of 54 years [45-63]. Patients with synovitis had more frequently lymph node enlargement (12.3% vs. 1.8%, p = .007) and a higher ESSDAI score (8 [6-12] vs. 2 [1-4], p < .0001). There was no difference concerning CRP levels, rheumatoid factor and cyclic citrullinated peptide (CCP)-antibodies positivity. Among 57 patients with synovitis, 101 various treatment courses have been used during the follow-up of 40 [22.5-77] months. First treatment course consisted in steroids alone (3.5%), steroids in association (79%) with hydroxychloroquine (HCQ) (49%), methotrexate (MTX) (35%), rituximab (RTX) (5.3%) or other immunosuppressive drugs (7%). HCQ, MTX, and RTX were associated with a significant reduction of tender and swollen joint count, and a significant steroids-sparing effect. No difference could be shown for the joint response between these treatment regimens.CONCLUSION: pSS articular manifestations may include synovitis which could mimic rheumatoid arthritis but differ by the absence of structural damage. Even if the use of HCQ, MTX, and RTX seem to be effective for joint involvement, the best regimen remains to be determined.</p> </div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Pays de la Loire</li><li>Île-de-France</li></region><settlement><li>Angers</li><li>Paris</li></settlement><orgName><li>Université Paris 13</li><li>Université d'Angers</li></orgName></list><tree><country name="France"><noRegion><name sortKey="Mirouse, Adrien" sort="Mirouse, Adrien" uniqKey="Mirouse A" first="Adrien" last="Mirouse">Adrien Mirouse</name></noRegion><name sortKey="Arlet, Jean Benoit" sort="Arlet, Jean Benoit" uniqKey="Arlet J" first="Jean-Benoît" last="Arlet">Jean-Benoît Arlet</name><name sortKey="Costedoat Chalumeau, Nathalie" sort="Costedoat Chalumeau, Nathalie" uniqKey="Costedoat Chalumeau N" first="Nathalie" last="Costedoat-Chalumeau">Nathalie Costedoat-Chalumeau</name><name sortKey="Dellal, Azeddine" sort="Dellal, Azeddine" uniqKey="Dellal A" first="Azeddine" last="Dellal">Azeddine Dellal</name><name sortKey="Denis, Guillaume" sort="Denis, Guillaume" uniqKey="Denis G" first="Guillaume" last="Denis">Guillaume Denis</name><name sortKey="Deroux, Alban" sort="Deroux, Alban" uniqKey="Deroux A" first="Alban" last="Deroux">Alban Deroux</name><name sortKey="Diallo, Abdou" sort="Diallo, Abdou" uniqKey="Diallo A" first="Abdou" last="Diallo">Abdou Diallo</name><name sortKey="Dougados, Maxime" sort="Dougados, Maxime" uniqKey="Dougados M" first="Maxime" last="Dougados">Maxime Dougados</name><name sortKey="Fain, Olivier" sort="Fain, Olivier" uniqKey="Fain O" first="Olivier" last="Fain">Olivier Fain</name><name sortKey="Fauchais, Anne Laure" sort="Fauchais, Anne Laure" uniqKey="Fauchais A" first="Anne-Laure" last="Fauchais">Anne-Laure Fauchais</name><name sortKey="Fischer Dumont, Dominique" sort="Fischer Dumont, Dominique" uniqKey="Fischer Dumont D" first="Dominique" last="Fischer-Dumont">Dominique Fischer-Dumont</name><name sortKey="Lavigne, Christian" sort="Lavigne, Christian" uniqKey="Lavigne C" first="Christian" last="Lavigne">Christian Lavigne</name><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name><name sortKey="Mekinian, Arsene" sort="Mekinian, Arsene" uniqKey="Mekinian A" first="Arsène" last="Mékinian">Arsène Mékinian</name><name sortKey="Sellam, Jeremie" sort="Sellam, Jeremie" uniqKey="Sellam J" first="Jeremie" last="Sellam">Jeremie Sellam</name><name sortKey="Seror, Raphaele" sort="Seror, Raphaele" uniqKey="Seror R" first="Raphaele" last="Séror">Raphaele Séror</name><name sortKey="Urbanski, Geoffrey" sort="Urbanski, Geoffrey" uniqKey="Urbanski G" first="Geoffrey" last="Urbanski">Geoffrey Urbanski</name><name sortKey="Vicaut, Eric" sort="Vicaut, Eric" uniqKey="Vicaut E" first="Eric" last="Vicaut">Eric Vicaut</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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